Investigation of Nanosized Crystalline Form to Improve the Oral Bioavailability of Poorly Water Soluble Cilostazol

• Main Authors: Xiaoqing Miao (Author), Changshan Sun (Author), Tongying Jiang (Author), Li Zheng (Author), Tianyi Wang (Author), Siling Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2011-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: The aim of this study was to develop cilostazol (CLT) nanocrystals intended to improve its dissolution rate and enhance its bioavailability. Methods: In this study, CLT nanosuspension was prepared by the anti-solvent and high-pressure homogenization method. The effects of the production par...