Development and Validation of the New Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Unbound Tacrolimus in the Plasma Ultrafiltrate of Transplant Recipients

• Main Authors: Magdalena Bodnar-Broniarczyk (Author), Karola Warzyszyńska (Author), Katarzyna Czerwińska (Author), Dorota Marszałek (Author), Natalia Dziewa (Author), Maciej Kosieradzki (Author), Tomasz Pawiński (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

(1) Background: Only unbound tacrolimus particles are considered to be active and capable of crossing cellular membranes. Thus, the free-drug concentration might be better associated with clinical effects than the total drug concentration used for dosage adjustment. We propose a new, fully validated...