Development and Validation of the New Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Unbound Tacrolimus in the Plasma Ultrafiltrate of Transplant Recipients

Development and Validation of the New Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Unbound Tacrolimus in the Plasma Ultrafiltrate of Transplant Recipients

(1) Background: Only unbound tacrolimus particles are considered to be active and capable of crossing cellular membranes. Thus, the free-drug concentration might be better associated with clinical effects than the total drug concentration used for dosage adjustment. We propose a new, fully validated...

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Main Authors: Magdalena Bodnar-Broniarczyk (Author), Karola Warzyszyńska (Author), Katarzyna Czerwińska (Author), Dorota Marszałek (Author), Natalia Dziewa (Author), Maciej Kosieradzki (Author), Tomasz Pawiński (Author)
Format: Book
Published: MDPI AG, 2022-03-01T00:00:00Z.
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