Development and Validation of the New Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Unbound Tacrolimus in the Plasma Ultrafiltrate of Transplant Recipients

• Päätekijät: Magdalena Bodnar-Broniarczyk (Tekijä), Karola Warzyszyńska (Tekijä), Katarzyna Czerwińska (Tekijä), Dorota Marszałek (Tekijä), Natalia Dziewa (Tekijä), Maciej Kosieradzki (Tekijä), Tomasz Pawiński (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2022-03-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

(1) Background: Only unbound tacrolimus particles are considered to be active and capable of crossing cellular membranes. Thus, the free-drug concentration might be better associated with clinical effects than the total drug concentration used for dosage adjustment. We propose a new, fully validated...