Characterization of Susceptibility Variants of Influenza Virus Grown in the Presence of T-705

• Main Authors: Tohru Daikoku (Author), Yoshihiro Yoshida (Author), Tomoko Okuda (Author), Kimiyasu Shiraki (Author)
• Formato: Livro
• Publicado em: Elsevier, 2014-04-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract.: T-705 (favipiravir) is a potent inhibitor of RNA polymerases of influenza viruses. Susceptibility variants were isolated during passages in the presence of T-705. Nine variants with 0.4 to 2.1 times the 50% inhibitory concentration for plaque formation of the parent A/PR/8/34 (H1N1) strai...