Design, synthesis and biological evaluation of novel diarylpyridine derivatives as tubulin polymerisation inhibitors

A set of novel diarylpyridines as anti-tubulin agents were designed, synthesised using a rigid pyridine as a linker to fix the cis-orientation of ring-A and ring-B. All of the target compounds were evaluated for their in vitro antiproliferative activities. Among them, 10t showed remarkable antiproli...

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Main Authors: Shanbo Yang (Author), Chao Wang (Author), Lingyu Shi (Author), Jing Chang (Author), Yujing Zhang (Author), Jingsen Meng (Author), Wenjing Liu (Author), Jun Zeng (Author), Renshuai Zhang (Author), Yingchun Shao (Author), Dongming Xing (Author)
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Publicado em: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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