Hesperetin Prevents Bone Resorption by Inhibiting RANKL-Induced Osteoclastogenesis and Jnk Mediated Irf-3/c-Jun Activation

• Main Authors: Qiang Zhang (Author), Xinqiao Tang (Author), Zhong Liu (Author), Xiaoxia Song (Author), Dan Peng (Author), Wei Zhu (Author), Zhengxiao Ouyang (Author), Wanchun Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bone homeostasis and resorption is regulated by the proper activation of osteoclasts, whose stimulation largely depends on the receptor activator of nuclear factor κB ligand (RANKL)-RANK signaling. Herein, for the first time, we showed that interferon regulatory factor (Irf)-3 was intimately involve...