Implementation of targeted next-generation sequencing for the diagnosis of drug-resistant tuberculosis in low-resource settings: a programmatic model, challenges, and initial outcomes

• Main Authors: Leonardo de Araujo (Author), Andrea Maurizio Cabibbe (Author), Lusia Mhuulu (Author), Nunurai Ruswa (Author), Viola Dreyer (Author), Azaria Diergaardt (Author), Gunar Günther (Author), Mareli Claassens (Author), Christiane Gerlach (Author), Christian Utpatel (Author), Daniela Maria Cirillo (Author), Emmanuel Nepolo (Author), Stefan Niemann (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Targeted next-generation sequencing (tNGS) from clinical specimens has the potential to become a comprehensive tool for routine drug-resistance (DR) prediction of Mycobacterium tuberculosis complex strains (MTBC), the causative agent of tuberculosis (TB). However, TB mainly affects low- and middle-i...