Application of Peptide Nucleic Acid-based Assays Toward Detection of Somatic Mosaicism

• Autori principali: Christopher S Hong (Autore), Chunzhang Yang (Autore), Zhengping Zhuang (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2016-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Peptide nucleic acids (PNAs) are synthetic oligonucleotides with many applications. Compared with DNA, PNAs bind their complementary DNA strand with higher specificity and strength, an attribute that can make it an effective polymerase chain reaction clamp. A growing body of work has demonstrated th...