Botanical drugs for treating erectile dysfunction: clinical evidence
Phosphodiesterase-5 inhibitors (PDE5-i) have been widely used in clinical practice for the treatment of erectile dysfunction (ED). However, due to its suboptimal therapeutic effects and side effects, it is necessary to develop new medicines for ED treatment. Botanical drugs have been widely investig...
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Frontiers Media S.A.,
2023-08-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_54d45b50c6594e95b301e105ec1a4d1b | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Dengjianyi Xu |e author |
| 700 | 1 | 0 | |a Yucong Zhang |e author |
| 700 | 1 | 0 | |a Jian Bai |e author |
| 700 | 1 | 0 | |a Huixing Yuan |e author |
| 700 | 1 | 0 | |a Tao Wang |e author |
| 700 | 1 | 0 | |a Jihong Liu |e author |
| 700 | 1 | 0 | |a Wen Song |e author |
| 700 | 1 | 0 | |a Delin Ma |e author |
| 245 | 0 | 0 | |a Botanical drugs for treating erectile dysfunction: clinical evidence |
| 260 | |b Frontiers Media S.A., |c 2023-08-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2023.1232774 | ||
| 520 | |a Phosphodiesterase-5 inhibitors (PDE5-i) have been widely used in clinical practice for the treatment of erectile dysfunction (ED). However, due to its suboptimal therapeutic effects and side effects, it is necessary to develop new medicines for ED treatment. Botanical drugs have been widely investigated as potential ED treatment drugs and have shown promising therapeutic effects. This review summarized 34 studies, including five botanical drugs with PDE5 inhibitory activity, seven botanical drugs without PDE5 inhibitory activity, and six mixed botanical drugs. The results of clinical studies regarding the aforementioned botanical drugs and relevant mechanisms are summarized in this study. It is necessary to conduct high-quality clinical trials to verify the dosage, targeted patients and therapeutic effects, and further pharmacology experiments are also needed to identify the active compounds. | ||
| 546 | |a EN | ||
| 690 | |a botanical drugs | ||
| 690 | |a natural products | ||
| 690 | |a erectile dysfunction | ||
| 690 | |a clinical study | ||
| 690 | |a phosphodiesterase-5 | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 14 (2023) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2023.1232774/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/54d45b50c6594e95b301e105ec1a4d1b |z Connect to this object online. |