Role of Ezrin/Radixin/Moesin in the Surface Localization of Programmed Cell Death Ligand-1 in Human Colon Adenocarcinoma LS180 Cells

• Autori principali: Takuro Kobori (Autore), Chihiro Tanaka (Autore), Mayuka Tameishi (Autore), Yoko Urashima (Autore), Takuya Ito (Autore), Tokio Obata (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2021-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Programmed cell death ligand-1 (PD-L1), an immune checkpoint protein highly expressed on the cell surface in various cancer cell types, binds to programmed cell death-1 (PD-1), leading to T-cell dysfunction and tumor survival. Despite clinical successes of PD-1/PD-L1 blockade therapies, patients wit...