Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models

Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models

Genetic mutations underlying neurodegenerative disorders impair ribosomal DNA (rDNA) transcription suggesting that nucleolar dysfunction could be a novel pathomechanism in polyglutamine diseases and in certain forms of amyotrophic lateral sclerosis/frontotemporal dementia. Here, we investigated nucl...

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Main Authors: Valentin Evsyukov (Author), Andrii Domanskyi (Author), Holger Bierhoff (Author), Suzana Gispert (Author), Rasem Mustafa (Author), Falk Schlaudraff (Author), Birgit Liss (Author), Rosanna Parlato (Author)
Format: Book
Published: The Company of Biologists, 2017-05-01T00:00:00Z.
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