Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models

• Hoofdauteurs: Valentin Evsyukov (Auteur), Andrii Domanskyi (Auteur), Holger Bierhoff (Auteur), Suzana Gispert (Auteur), Rasem Mustafa (Auteur), Falk Schlaudraff (Auteur), Birgit Liss (Auteur), Rosanna Parlato (Auteur)
• Formaat: Boek
• Gepubliceerd in: The Company of Biologists, 2017-05-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Genetic mutations underlying neurodegenerative disorders impair ribosomal DNA (rDNA) transcription suggesting that nucleolar dysfunction could be a novel pathomechanism in polyglutamine diseases and in certain forms of amyotrophic lateral sclerosis/frontotemporal dementia. Here, we investigated nucl...