The Chromatin Structure of CRISPR-Cas9 Target DNA Controls the Balance between Mutagenic and Homology-Directed Gene-Editing Events
Gene editing based on homology-directed repair (HDR) depends on donor DNA templates and programmable nucleases, e.g., RNA-guided CRISPR-Cas9 nucleases. However, next to inducing HDR involving the mending of chromosomal double-stranded breaks (DSBs) with donor DNA substrates, programmable nucleases a...
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| Main Authors: | , , , |
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| Format: | Book |
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Elsevier,
2019-06-01T00:00:00Z.
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| Call Number: |
A1234.567 |
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| Copy 1 | Available |