The Chromatin Structure of CRISPR-Cas9 Target DNA Controls the Balance between Mutagenic and Homology-Directed Gene-Editing Events

• Κύριοι συγγραφείς: Josephine M. Janssen (Συγγραφέας), Xiaoyu Chen (Συγγραφέας), Jin Liu (Συγγραφέας), Manuel A.F.V. Gonçalves (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Elsevier, 2019-06-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Gene editing based on homology-directed repair (HDR) depends on donor DNA templates and programmable nucleases, e.g., RNA-guided CRISPR-Cas9 nucleases. However, next to inducing HDR involving the mending of chromosomal double-stranded breaks (DSBs) with donor DNA substrates, programmable nucleases a...