Polymeric Nanoparticles Enable mRNA Transfection and Its Translation in Intervertebral Disc and Human Joint Cells, Except for M1 Macrophages

• Main Authors: Katrin Agnes Muenzebrock (Author), Fiona Y. W. Ho (Author), Adriano P. Pontes (Author), Carla Jorquera-Cordero (Author), Lizette Utomo (Author), Joao Pedro Garcia (Author), Paul C. Willems (Author), Tim J. M. Welting (Author), Jaap Rip (Author), Laura B. Creemers (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic lower back pain caused by intervertebral disc degeneration and osteoarthritis (OA) are highly prevalent chronic diseases. Although pain management and surgery can alleviate symptoms, no disease-modifying treatments are available. mRNA delivery could halt inflammation and degeneration and ind...