Synthesis and biological evaluation of benzothiazin-4-ones: a possible new class of acetylcholinesterase inhibitors

• Main Authors: Gabriele A. Berwaldt (Author), Daniela P. Gouvêa (Author), Daniel S. da Silva (Author), Adriana M. das Neves (Author), Mayara S. P. Soares (Author), Juliana H. Azambuja (Author), Geonir M. Siqueira (Author), Roselia M. Spanevello (Author), Wilson Cunico (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of nineteen benzothiazin-4-ones from N-(3-aminopropyl) piperidine, 4-(2-aminoethyl)morpholine or 1-(2-aminoethyl)piperidine, aliphatic or aromatic aldehyde and thiosalicylic acid, were synthesized in good yields by multicomponent one-pot reactions. The solvent was toluene and this efficient...