The pH-dependence of efflux ratios determined with bidirectional transport assays across cellular monolayers
MDCK/Caco-2 assays serve as essential in vitro tools for evaluating membrane permeability and active transport, especially mediated by P-glycoprotein (P-gp). Despite their utility, challenges remain in quantifying active transport and using the efflux ratio (ER) to determine intrinsic values for act...
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Elsevier,
2024-12-01T00:00:00Z.
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