Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease

• Main Authors: Julia C. Wilmanns (Author), Raghav Pandey (Author), Olivia Hon (Author), Anjana Chandran (Author), Jan M. Schilling (Author), Elvira Forte (Author), Qizhu Wu (Author), Gael Cagnone (Author), Preeti Bais (Author), Vivek Philip (Author), David Coleman (Author), Heidi Kocalis (Author), Stuart K. Archer (Author), James T. Pearson (Author), Mirana Ramialison (Author), Joerg Heineke (Author), Hemal H. Patel (Author), Nadia A. Rosenthal (Author), Milena B. Furtado (Author), Mauro W. Costa (Author)
• Format: Book
• Published: Elsevier, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Congenital heart disease (CHD) is the most frequent birth defect worldwide. The number of adult patients with CHD, now referred to as ACHD, is increasing with improved surgical and treatment interventions. However the mechanisms whereby ACHD predisposes patients to heart dysfunction are s...