CIRP attenuates acute kidney injury after hypothermic cardiovascular surgery by inhibiting PHD3/HIF-1α-mediated ROS-TGF-β1/p38 MAPK activation and mitochondrial apoptotic pathways

• Main Authors: Peiyao Zhang (Author), Liting Bai (Author), Yuanyuan Tong (Author), Shengwen Guo (Author), Wenlong Lu (Author), Yue Yuan (Author), Wenting Wang (Author), Yu Jin (Author), Peng Gao (Author), Jinping Liu (Author)
• Format: Book
• Published: BMC, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The ischemia-reperfusion (IR) environment during deep hypothermic circulatory arrest (DHCA) cardiovascular surgery is a major cause of acute kidney injury (AKI), which lacks preventive measure and treatment. It was reported that cold inducible RNA-binding protein (CIRP) can be in...