CIRP attenuates acute kidney injury after hypothermic cardiovascular surgery by inhibiting PHD3/HIF-1α-mediated ROS-TGF-β1/p38 MAPK activation and mitochondrial apoptotic pathways

• Hoofdauteurs: Peiyao Zhang (Auteur), Liting Bai (Auteur), Yuanyuan Tong (Auteur), Shengwen Guo (Auteur), Wenlong Lu (Auteur), Yue Yuan (Auteur), Wenting Wang (Auteur), Yu Jin (Auteur), Peng Gao (Auteur), Jinping Liu (Auteur)
• Formaat: Boek
• Gepubliceerd in: BMC, 2023-05-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Abstract Background The ischemia-reperfusion (IR) environment during deep hypothermic circulatory arrest (DHCA) cardiovascular surgery is a major cause of acute kidney injury (AKI), which lacks preventive measure and treatment. It was reported that cold inducible RNA-binding protein (CIRP) can be in...