CIRP attenuates acute kidney injury after hypothermic cardiovascular surgery by inhibiting PHD3/HIF-1α-mediated ROS-TGF-β1/p38 MAPK activation and mitochondrial apoptotic pathways

• Egile Nagusiak: Peiyao Zhang (Egilea), Liting Bai (Egilea), Yuanyuan Tong (Egilea), Shengwen Guo (Egilea), Wenlong Lu (Egilea), Yue Yuan (Egilea), Wenting Wang (Egilea), Yu Jin (Egilea), Peng Gao (Egilea), Jinping Liu (Egilea)
• Formatua: Liburua
• Argitaratua: BMC, 2023-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Abstract Background The ischemia-reperfusion (IR) environment during deep hypothermic circulatory arrest (DHCA) cardiovascular surgery is a major cause of acute kidney injury (AKI), which lacks preventive measure and treatment. It was reported that cold inducible RNA-binding protein (CIRP) can be in...