Age-related dysfunction of the DNA damage response in intestinal stem cells

• Main Authors: Koichiro Watanabe (Author), Yasuaki Ikuno (Author), Yumi Kakeya (Author), Shinsuke Ikeno (Author), Hitomi Taniura (Author), Masayoshi Kurono (Author), Keito Minemori (Author), Yu Katsuyama (Author), Hayato Naka-Kaneda (Author)
• Format: Book
• Published: BMC, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Senescence increases the risks of inflammatory bowel diseases and colon cancer. Intestinal stem cells (ISCs) in crypts differentiate into epithelial cells and thereby maintain intestinal homeostasis. However, the influence of aging on the functions of ISCs is largely unknown. The...