The Novel Compounds That Activate Farnesoid X Receptor: the Diversity of Their Effects on Gene Expression

• Main Authors: Takuo Suzuki (Author), Norimasa Tamehiro (Author), Yoji Sato (Author), Tetsu Kobayashi (Author), Akiko Ishii-Watabe (Author), Youichi Shinozaki (Author), Tomoko Nishimaki-Mogami (Author), Toshihiro Hashimoto (Author), Yoshinori Asakawa (Author), Kazuhide Inoue (Author), Yasuo Ohno (Author), Teruhide Yamaguchi (Author), Toru Kawanishi (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Farnesoid X receptor (FXR) controls the expression of critical genes in bile acid and cholesterol homeostasis. To study FXR and to develop a regulator of cholesterol, some nonsteroidal and steroidal ligands have been found in addition to endogenous ligands for FXR. In this study, we discovered five...