The Leukemic Stem Cell Niche: Adaptation to "Hypoxia" versus Oncogene Addiction

• Main Authors: Giulia Cheloni (Author), Martina Poteti (Author), Silvia Bono (Author), Erico Masala (Author), Nathalie M. Mazure (Author), Elisabetta Rovida (Author), Matteo Lulli (Author), Persio Dello Sbarba (Author)
• Formato: Livro
• Publicado em: Hindawi Limited, 2017-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Previous studies based on low oxygen concentrations in the incubation atmosphere revealed that metabolic factors govern the maintenance of normal hematopoietic or leukemic stem cells (HSC and LSC). The physiological oxygen concentration in tissues ranges between 0.1 and 5.0%. Stem cell niches (SCN)...