Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve

• Main Authors: Rebecca M. Klein (Author), Mark E. Layton (Author), Hillary Regan (Author), Christopher P. Regan (Author), Yuxing Li (Author), Tracey Filzen (Author), Matt Cato (Author), Michelle K. Clements (Author), Jixin Wang (Author), Raul Sanoja (Author), Thomas J. Greshock (Author), Anthony J. Roecker (Author), Joseph E. Pero (Author), Ron Kim (Author), Christopher Burgey (Author), Christopher T. John (Author), Ying-Hong Wang (Author), Neetesh Bhandari (Author), Arie Struyk (Author), Richard L. Kraus (Author), Darrell A. Henze (Author), Andrea K. Houghton (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As part of a drug discovery effort to identify potent inhibitors of NaV1.7 for the treatment of pain, we observed that inhibitors produced unexpected cardiovascular and respiratory effects in vivo. Specifically, inhibitors administered to rodents produced changes in cardiovascular parameters and res...