The basics of CAR T design and challenges in immunotherapy of solid tumors - Ovarian cancer as a model

• المؤلفون الرئيسيون: Xuequn Xu (مؤلف), Jin Qiu (مؤلف), Yi Sun (مؤلف)
• التنسيق: كتاب
• منشور في: Taylor & Francis Group, 2017-07-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Chimeric antigen receptor T cells are T cells genetically engineered with CAR constructs which mainly contain scFV and TCR zeta chain. With promising development in blood cancers, CAR T trials are also applied in solid cancers. However, the treatment effect in solid cancers is lower than expected. T...