Supramolecular Arrangement of Doxycycline with Sulfobutylether-β-Cyclodextrin: Impact on Nanostructuration with Chitosan, Drug Degradation and Antimicrobial Potency

• Main Authors: Renata Carvalho Feitosa (Author), Juliana Souza Ribeiro Costa (Author), Marcelo van Vliet Lima (Author), Elina Sawa Akioka Ishikawa (Author), Karina Cogo Müller (Author), Fernando Bonin Okasaki (Author), Edvaldo Sabadini (Author), Claudia Garnero (Author), Marcela Raquel Longhi (Author), Vladimir Lavayen (Author), Arnóbio Antônio da Silva-Júnior (Author), Laura Oliveira-Nascimento (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Doxycycline (DX) is a well-established and broad-spectrum antimicrobial drug. However, DX has drawbacks, such as physicochemical instability in aqueous media and bacterial resistance. The inclusion of drugs in cyclodextrin complexes and their loading into nanocarriers can overcome these limitations....