Compartmentalized Polymeric Nanoparticles Deliver Vancomycin in a pH-Responsive Manner

• Main Authors: Merve Seray Ural (Author), Mario Menéndez-Miranda (Author), Giuseppina Salzano (Author), Jérémie Mathurin (Author), Ece Neslihan Aybeke (Author), Ariane Deniset-Besseau (Author), Alexandre Dazzi (Author), Marianna Porcino (Author), Charlotte Martineau-Corcos (Author), Ruxandra Gref (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vancomycin (VCM) is a last resort antibiotic in the treatment of severe Gram-positive infections. However, its administration is limited by several drawbacks such as: strong pH-dependent charge, tendency to aggregate, low bioavailability, and poor cellular uptake. These drawbacks were circumvented b...