Compartmentalized Polymeric Nanoparticles Deliver Vancomycin in a pH-Responsive Manner

• 主要な著者: Merve Seray Ural (著者), Mario Menéndez-Miranda (著者), Giuseppina Salzano (著者), Jérémie Mathurin (著者), Ece Neslihan Aybeke (著者), Ariane Deniset-Besseau (著者), Alexandre Dazzi (著者), Marianna Porcino (著者), Charlotte Martineau-Corcos (著者), Ruxandra Gref (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2021-11-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Vancomycin (VCM) is a last resort antibiotic in the treatment of severe Gram-positive infections. However, its administration is limited by several drawbacks such as: strong pH-dependent charge, tendency to aggregate, low bioavailability, and poor cellular uptake. These drawbacks were circumvented b...