Dual SMO/BRAF Inhibition by Flavonolignans from <i>Silybum marianum</i>

• Main Authors: Antonia Diukendjieva (Author), Maya M. Zaharieva (Author), Mattia Mori (Author), Petko Alov (Author), Ivanka Tsakovska (Author), Tania Pencheva (Author), Hristo Najdenski (Author), Vladimír Křen (Author), Chiara Felici (Author), Francesca Bufalieri (Author), Lucia Di Marcotullio (Author), Bruno Botta (Author), Maurizio Botta (Author), Ilza Pajeva (Author)
• Format: Book
• Published: MDPI AG, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Silymarin is the standardized extract from the fruits of <i>Silybum marianum</i> (L.) Gaertn., a well-known hepatoprotectant and antioxidant. Recently, bioactive compounds of silymarin, i.e., silybins and their 2,3-dehydro derivatives, have been shown to exert anticancer activities, yet...