LSD1 inhibitors for cancer treatment: Focus on multi-target agents and compounds in clinical trials

Histone lysine-specific demethylase 1 (LSD1/KDM1A) was first identified in 2004 as an epigenetic enzyme able to demethylate specific lysine residues of histone H3, namely H3K4me1/2 and H3K9me1/2, using FAD as the cofactor. It is ubiquitously overexpressed in many types of cancers (breast, gastric, p...

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Main Authors: Beatrice Noce (Author), Elisabetta Di Bello (Author), Rossella Fioravanti (Author), Antonello Mai (Author)
Format: Knjiga
Izdano: Frontiers Media S.A., 2023-02-01T00:00:00Z.
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