LSD1 inhibitors for cancer treatment: Focus on multi-target agents and compounds in clinical trials
Histone lysine-specific demethylase 1 (LSD1/KDM1A) was first identified in 2004 as an epigenetic enzyme able to demethylate specific lysine residues of histone H3, namely H3K4me1/2 and H3K9me1/2, using FAD as the cofactor. It is ubiquitously overexpressed in many types of cancers (breast, gastric, p...
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Frontiers Media S.A.,
2023-02-01T00:00:00Z.
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