Aerobic exercise-induced HIF-1α upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation

• Main Authors: Longfei Xu (Author), Miaomiao Yang (Author), Aili Wei (Author), Zilin Wei (Author), Yingkai Qin (Author), Kun Wang (Author), Bin Li (Author), Kang Chen (Author), Chen Liu (Author), Chao Li (Author), Tianhui Wang (Author)
• Format: Book
• Published: BMC, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The terminal stage of ischemic heart disease develops into heart failure (HF), which is characterized by hypoxia and metabolic disturbances in cardiomyocytes. The hypoxic failing heart triggers hypoxia-inducible factor-1α (HIF-1α) actions in the cells sensitized to hypoxia and in...