Anticancer Activity of Urease Mimetic Cobalt (III) Complexes on A549-Lung Cancer Cells: Targeting the Acidic Microenvironment

Tumour cells maintain a local hypoxic and acidic microenvironment which plays a crucial role in cancer progression and drug resistance. Urease is a metallohydrolases that catalyses the hydrolysis of urea into ammonia and carbon dioxide, causing an abrupt increase of pH. This enzymatic activity can b...

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Main Authors: Bhawna Uprety (Author), Rahul Chandran (Author), Charmaine Arderne (Author), Heidi Abrahamse (Author)
Format: Book
Published: MDPI AG, 2022-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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