Anticancer Activity of Urease Mimetic Cobalt (III) Complexes on A549-Lung Cancer Cells: Targeting the Acidic Microenvironment

• Главные авторы: Bhawna Uprety (Автор), Rahul Chandran (Автор), Charmaine Arderne (Автор), Heidi Abrahamse (Автор)
• Формат: ‌
• Опубликовано: MDPI AG, 2022-01-01T00:00:00Z.
• Предметы: article
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Tumour cells maintain a local hypoxic and acidic microenvironment which plays a crucial role in cancer progression and drug resistance. Urease is a metallohydrolases that catalyses the hydrolysis of urea into ammonia and carbon dioxide, causing an abrupt increase of pH. This enzymatic activity can b...