Anticancer Activity of Urease Mimetic Cobalt (III) Complexes on A549-Lung Cancer Cells: Targeting the Acidic Microenvironment

• Κύριοι συγγραφείς: Bhawna Uprety (Συγγραφέας), Rahul Chandran (Συγγραφέας), Charmaine Arderne (Συγγραφέας), Heidi Abrahamse (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2022-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Tumour cells maintain a local hypoxic and acidic microenvironment which plays a crucial role in cancer progression and drug resistance. Urease is a metallohydrolases that catalyses the hydrolysis of urea into ammonia and carbon dioxide, causing an abrupt increase of pH. This enzymatic activity can b...