Insights into the Small Molecule Targeting of Biologically Relevant G-Quadruplexes: An Overview of NMR and Crystal Structures

• Auteurs principaux: Andrea Criscuolo (Auteur), Ettore Napolitano (Auteur), Claudia Riccardi (Auteur), Domenica Musumeci (Auteur), Chiara Platella (Auteur), Daniela Montesarchio (Auteur)
• Format: Livre
• Publié: MDPI AG, 2022-11-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

G-quadruplexes turned out to be important targets for the development of novel targeted anticancer/antiviral therapies. More than 3000 G-quadruplex small-molecule ligands have been described, with most of them exerting anticancer/antiviral activity by inducing telomeric damage and/or altering oncoge...