The Amorphous Solid Dispersion of Chrysin in Plasdone^® S630 Demonstrates Improved Oral Bioavailability and Antihyperlipidemic Performance in Rats

• Main Authors: Chenhui Wang (Author), Xiaowei Liu (Author), Ruihan Zhao (Author), Meiqing Yang (Author), Wenqian Liu (Author), Qiuyang Dai (Author), Xiaofeng Bao (Author), Yong Chen (Author), Jun Ma (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chrysin is a flavonoid with various biological activities. However, its low water solubility and strong metabolism render its oral bioavailability rather poor. This study aimed to develop a stable solid dispersion formulation of chrysin to improve the dissolution of chrysin, so as to increase its or...