Novel genomic variants influencing methotrexate delayed clearance in pediatric patients with acute lymphoblastic leukemia

• Main Authors: Jung Yoon Choi (Author), Hoshik Kwon (Author), Hyery Kim (Author), Kyung Taek Hong (Author), Youngeun Ma (Author), Kyung-Nam Koh (Author), Sunmin Yun (Author), Keon Hee Yoo (Author), Sang Hoon Song (Author), Ho Joon Im (Author), Ju Han Kim (Author), Hyoung Jin Kang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundMethotrexate (MTX) is the primary drug used in the treatment of pediatric acute lymphoblastic leukemia (ALL). However, some patients exhibit delayed clearance of high-dose (HD) MTX, which induces severe nephrotoxicity, mucositis, hepatotoxicity, and neurotoxicity. We sought to identify rel...