Preventive and Alleviative Effect of Tramadol on Neuropathic Pain in Rats: Roles of α2-Adrenoceptors and Spinal Astrocytes

• Glavni autori: Minoru Sakakiyama (Autor), Sanae Maeda (Autor), Kouichi Isami (Autor), Kayoko Asakura (Autor), Kanako So (Autor), Hisashi Shirakawa (Autor), Takayuki Nakagawa (Autor), Shuji Kaneko (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2014-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

The acute analgesic effect of tramadol has been extensively investigated; however, its long-term effect on neuropathic pain has not been well clarified. In this study, we examined the effects of repeated administration of tramadol on partial sciatic nerve ligation-induced neuropathic pain in rats. E...