Preventive and Alleviative Effect of Tramadol on Neuropathic Pain in Rats: Roles of α2-Adrenoceptors and Spinal Astrocytes

• Main Authors: Minoru Sakakiyama (Author), Sanae Maeda (Author), Kouichi Isami (Author), Kayoko Asakura (Author), Kanako So (Author), Hisashi Shirakawa (Author), Takayuki Nakagawa (Author), Shuji Kaneko (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The acute analgesic effect of tramadol has been extensively investigated; however, its long-term effect on neuropathic pain has not been well clarified. In this study, we examined the effects of repeated administration of tramadol on partial sciatic nerve ligation-induced neuropathic pain in rats. E...