Dysregulated transcriptional networks in KMT2A- and MLLT10-rearranged T-ALL

• Main Authors: Huining Kang (Author), Nitesh D. Sharma (Author), Christian K. Nickl (Author), Meenakshi Devidas (Author), Mignon L. Loh (Author), Stephen P. Hunger (Author), Kimberly P. Dunsmore (Author), Stuart S. Winter (Author), Ksenia Matlawska-Wasowska (Author)
• Format: Book
• Published: BMC, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract For children and young adults with T-lineage acute lymphoblastic leukemia (T-ALL), event free survival following relapse is < 10%. We recently showed that rearrangements of the mixed lineage leukemia gene (KMT2A-R) are associated with induction failure and an inferior survival in T-ALL....