Non-small cell lung cancer sensitisation to platinum chemotherapy via new thiazole-triazole hybrids acting as dual T-type CCB/MMP-9 inhibitors

• Główni autorzy: Hassan Gamal (Autor), Khadiga A. Ismail (Autor), A-Mohsen M. E. Omar (Autor), Mohamed Teleb (Autor), Marwa M. Abu-Serie (Autor), Sun Huang (Autor), Abdalla S. Abdelsattar (Autor), Gerald W. Zamponi (Autor), Hesham Fahmy (Autor)
• Format: Książka
• Wydane: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Cisplatin remains the unchallenged standard therapy for NSCLC. However, it is not completely curative due to drug resistance and oxidative stress-induced toxicity. Drug resistance is linked to overexpression of matrix metalloproteinases (MMPs) and aberrant calcium signalling. We report synthesis of...