Non-small cell lung cancer sensitisation to platinum chemotherapy via new thiazole-triazole hybrids acting as dual T-type CCB/MMP-9 inhibitors

• Main Authors: Hassan Gamal (Author), Khadiga A. Ismail (Author), A-Mohsen M. E. Omar (Author), Mohamed Teleb (Author), Marwa M. Abu-Serie (Author), Sun Huang (Author), Abdalla S. Abdelsattar (Author), Gerald W. Zamponi (Author), Hesham Fahmy (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cisplatin remains the unchallenged standard therapy for NSCLC. However, it is not completely curative due to drug resistance and oxidative stress-induced toxicity. Drug resistance is linked to overexpression of matrix metalloproteinases (MMPs) and aberrant calcium signalling. We report synthesis of...