Application of Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions between Elexacaftor/Tezacaftor/Ivacaftor and Tacrolimus in Lung Transplant Recipients

Elexacaftor/tezacaftor/ivacaftor (ETI) treatment has potential benefits in lung transplant recipients, including improvements in extrapulmonary manifestations, such as gastrointestinal and sinus disease; however, ivacaftor is an inhibitor of cytochrome P450 3A (CYP3A) and may, therefore, pose a risk...

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Main Authors: Eunjin Hong (Author), Eugeniu Carmanov (Author), Alan Shi (Author), Peter S. Chung (Author), Adupa P. Rao (Author), Kevin Forrester (Author), Paul M. Beringer (Author)
Format: Book
Published: MDPI AG, 2023-05-01T00:00:00Z.
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3rd Floor Main Library

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