Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a.

• Main Authors: Thomas C Darton (Author), Claire Jones (Author), Christoph J Blohmke (Author), Claire S Waddington (Author), Liqing Zhou (Author), Anna Peters (Author), Kathryn Haworth (Author), Rebecca Sie (Author), Christopher A Green (Author), Catherine A Jeppesen (Author), Maria Moore (Author), Ben A V Thompson (Author), Tessa John (Author), Robert A Kingsley (Author), Ly-Mee Yu (Author), Merryn Voysey (Author), Zoe Hindle (Author), Stephen Lockhart (Author), Marcelo B Sztein (Author), Gordon Dougan (Author), Brian Angus (Author), Myron M Levine (Author), Andrew J Pollard (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Typhoid persists as a major cause of global morbidity. While several licensed vaccines to prevent typhoid are available, they are of only moderate efficacy and unsuitable for use in children less than two years of age. Development of new efficacious vaccines is complicated by the human ho...