Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a.

• मुख्य लेखकों: Thomas C Darton (लेखक), Claire Jones (लेखक), Christoph J Blohmke (लेखक), Claire S Waddington (लेखक), Liqing Zhou (लेखक), Anna Peters (लेखक), Kathryn Haworth (लेखक), Rebecca Sie (लेखक), Christopher A Green (लेखक), Catherine A Jeppesen (लेखक), Maria Moore (लेखक), Ben A V Thompson (लेखक), Tessa John (लेखक), Robert A Kingsley (लेखक), Ly-Mee Yu (लेखक), Merryn Voysey (लेखक), Zoe Hindle (लेखक), Stephen Lockhart (लेखक), Marcelo B Sztein (लेखक), Gordon Dougan (लेखक), Brian Angus (लेखक), Myron M Levine (लेखक), Andrew J Pollard (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Public Library of Science (PLoS), 2016-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

BACKGROUND:Typhoid persists as a major cause of global morbidity. While several licensed vaccines to prevent typhoid are available, they are of only moderate efficacy and unsuitable for use in children less than two years of age. Development of new efficacious vaccines is complicated by the human ho...