Early detection of pre-malignant lesions in a KRASG12D-driven mouse lung cancer model by monitoring circulating free DNA

• Päätekijät: Callum P. Rakhit (Tekijä), Ricky M. Trigg (Tekijä), John Le Quesne (Tekijä), Michael Kelly (Tekijä), Jacqueline A. Shaw (Tekijä), Catrin Pritchard (Tekijä), L. Miguel Martins (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: The Company of Biologists, 2019-02-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Lung cancer is the leading cause of cancer-related death. Two-thirds of cases are diagnosed at an advanced stage that is refractory to curative treatment. Therefore, strategies for the early detection of lung cancer are urgently sought. Total circulating free DNA (cfDNA) and tumour-derived circulati...