Retina-Targeted Delivery of 17β-Estradiol by the Topically Applied DHED Prodrug

• Main Authors: Katalin Prokai-Tatrai (Author), Vien Nguyen (Author), Daniel L. De La Cruz (Author), Rebecca Guerra (Author), Khadiza Zaman (Author), Fatima Rahlouni (Author), Laszlo Prokai (Author)
• Format: Book
• Published: MDPI AG, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purpose of this study was to explore retina-targeted delivery of 17β-estradiol (E2), a powerful neuroprotectant, by its bioprecursor prodrug 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) administered as eye drops in animal models. Compared to the parent hormone, DHED displayed increased transcorn...