Hepatic synthesis of triacylglycerols containing medium-chain fatty acids is dominated by diacylglycerol acyltransferase 1 and efficiently inhibited by etomoxir

• Principais autores: Klaus Wunderling (Autor), Christina Leopold (Autor), Isabell Jamitzky (Autor), Mohamed Yaghmour (Autor), Fabian Zink (Autor), Dagmar Kratky (Autor), Christoph Thiele (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2021-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Objective: Medium-chain fatty acids (MCFAs) play an increasing role in human nutrition. In the liver, one fraction is used for synthesis of MCFA-containing triacylglycerol (MCFA-TG), and the rest is used for oxidative energy production or ketogenesis. We investigated which enzymes catalyse the synth...