N-myristoylation of Antimicrobial Peptide CM4 Enhances Its Anticancer Activity by Interacting With Cell Membrane and Targeting Mitochondria in Breast Cancer Cells

• Main Authors: Caiyun Li (Author), Hongyan Liu (Author), Yunqing Yang (Author), Xixi Xu (Author), Tongtong Lv (Author), Huidan Zhang (Author), Kehang Liu (Author), Shuangquan Zhang (Author), Yuqing Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Development of antimicrobial peptides (AMPs) as highly effective and selective anticancer agents would represent great progress in cancer treatment. Here we show that myristoyl-CM4, a new synthetic analog generated by N-myristoylation of AMPs CM4, had anticancer activity against MCF-7, MDA-MB-231, M...