Dedifferentiation of B-lymphoblastic leukemia/lymphoma with t(9;22) BCR::ABL1 to an undifferentiated neoplasm with strong keratin expression in a patient receiving blinatumomab

• Main Authors: Krasimira A. Rozenova (Author), Anja C. Roden (Author), Christopher Hartley (Author), Jess F. Peterson (Author), Gregory E. Otteson (Author), Aref Al-Kali (Author), Harry E. Fuentes Bayne (Author), Mithun V. Shah (Author), Mrinal S. Patnaik (Author), Rebecca L. King (Author), Daniel P. Larson (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Lineage switch in patients with B-ALL treated with blinatumomab has been previously reported. We present a case of blinatumomab-treated B-ALL with t(9;22)(q34.1;q11.2) (Ph + B-ALL) relapsing as a keratin-positive undifferentiated neoplasm with lack of B-cell, T-cell, or definitive myeloi...