Vasoinhibins Prevent Bradykinin-Stimulated Endothelial Cell Proliferation by Inactivating eNOS via Reduction of both Intracellular Ca2+ Levels and eNOS Phosphorylation at Ser1179

• Main Authors: Carmen Clapp (Author), Stéphanie Thebault (Author), Gonzalo Martínez De la Escalera (Author), Fernando López-Casillas (Author), Luis Vaca (Author), David Arredondo Zamarripa (Author), Gabriel Nava (Author), Celina García (Author), Carmen González (Author)
• Format: Book
• Published: MDPI AG, 2011-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vasoinhibins, a family of antiangiogenic peptides derived from prolactin proteolysis, inhibit the vascular effects of several proangiogenic factors, including bradykinin (BK). Here, we report that vasoinhibins block the BK-induced proliferation of bovine umbilical vein endothelial cells. This effect...