Xanthohumol, a Prenylated Flavonoid from Hops, Induces Caspase-Dependent Degradation of Oncoprotein BCR-ABL in K562 Cells

• मुख्य लेखकों: Xuxiu Lu (लेखक), Jiajia Geng (लेखक), Jinman Zhang (लेखक), Jinlai Miao (लेखक), Ming Liu (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2019-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

BCR-ABL oncoprotein drives the initiation, promotion, and progression of chronic myelogenous leukemia (CML). Tyrosine kinase inhibitors are the first choice for CML therapy, however, BCR-ABL mediated drug resistance limits its clinical application and prognosis. A novel promising therapeutic strateg...