Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload

• Main Authors: Sandro Altamura (Author), Katja Müdder (Author), Andrea Schlotterer (Author), Thomas Fleming (Author), Elena Heidenreich (Author), Ruiyue Qiu (Author), Hans-Peter Hammes (Author), Peter Nawroth (Author), Martina U. Muckenthaler (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The molecular pathogenesis of late complications associated with type 2 diabetes mellitus (T2DM) is not yet fully understood. While high glucose levels indicated by increased HbA1c only poorly explain disease progression and late complications, a pro-inflammatory status, oxidative stress,...