Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons

• Main Authors: Gillian Cady (Author), Taylor Landeryou (Author), Michael Garratt (Author), John J. Kopchick (Author), Nathan Qi (Author), David Garcia-Galiano (Author), Carol F. Elias (Author), Martin G. Myers, Jr (Author), Richard A. Miller (Author), Darleen A. Sandoval (Author), Marianna Sadagurski (Author)
• Format: Book
• Published: Elsevier, 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The GH/IGF-1 axis has important roles in growth and metabolism. GH and GH receptor (GHR) are active in the central nervous system (CNS) and are crucial in regulating several aspects of metabolism. In the hypothalamus, there is a high abundance of GH-responsive cells, but the role of GH si...