Inhibition of gasdermin D-dependent pyroptosis attenuates the progression of silica-induced pulmonary inflammation and fibrosis

• Main Authors: Meiyue Song (Author), Jiaxin Wang (Author), Youliang Sun (Author), Junling Pang (Author), Xiaona Li (Author), Yuan Liu (Author), Yitian Zhou (Author), Peiran Yang (Author), Tianhui Fan (Author), Ying Liu (Author), Zhaoguo Li (Author), Xianmei Qi (Author), Baicun Li (Author), Xinri Zhang (Author), Jing Wang (Author), Chen Wang (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Silicosis is a leading cause of occupational disease-related morbidity and mortality worldwide, but the molecular basis underlying its development remains unclear. An accumulating body of evidence supports gasdermin D (GSDMD)-mediated pyroptosis as a key component in the development of various pulmo...