In vitro modulation of multidrug resistance by pregnane steroids and in vivo inhibition of tumour development by 7α-OBz-11α(R)-OTHP-5β-pregnanedione in K562/R7 and H295R cell xenografts

• Main Authors: Ghina Alameh (Author), Agnès Emptoz-Bonneton (Author), Marc Rolland de Ravel (Author), Eva L. Matera (Author), Elisabeth Mappus (Author), Patrick Balaguer (Author), Luc Rocheblave (Author), Thierry Lomberget (Author), Charles Dumontet (Author), Marc Le Borgne (Author), Michel Pugeat (Author), Catherine Grenot (Author), Claude Y. Cuilleron (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Synthetic progesterone and 5α/β-pregnane-3,20-dione derivatives were evaluated as in vitro and in vivo modulators of multidrug-resistance (MDR) using two P-gp-expressing human cell lines, the non-steroidogenic K562/R7 erythroleukaemia cells and the steroidogenic NCI-H295R adrenocortical carcinoma ce...