Dose-Dependent Von Willebrand Factor Inhibition by Aptamer BB-031 Correlates with Thrombolysis in a Microfluidic Model of Arterial Occlusion

Dose-Dependent Von Willebrand Factor Inhibition by Aptamer BB-031 Correlates with Thrombolysis in a Microfluidic Model of Arterial Occlusion

Von Willebrand Factor (VWF) plays a critical role in thrombus formation, stabilization, and propagation. Previous studies have demonstrated that targeted inhibition of VWF induces thrombolysis when administered in vivo in animal models of ischemic stroke. The study objective was to quantify dose-dep...

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Main Authors: Susan M. Shea (Author), Kimberly A. Thomas (Author), Rassam M. G. Rassam (Author), Emily P. Mihalko (Author), Christina Daniel (Author), Bruce A. Sullenger (Author), Philip C. Spinella (Author), Shahid M. Nimjee (Author)
Format: Book
Published: MDPI AG, 2022-11-01T00:00:00Z.
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3rd Floor Main Library

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