A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus.

• Main Authors: Diogo M Magnani (Author), Cassia G T Silveira (Author), Brandon C Rosen (Author), Michael J Ricciardi (Author), Núria Pedreño-Lopez (Author), Martin J Gutman (Author), Varian K Bailey (Author), Helen S Maxwell (Author), Aline Domingues (Author), Lucas Gonzalez-Nieto (Author), Vivian I Avelino-Silva (Author), Mateus Trindade (Author), Juliana Nogueira (Author), Consuelo S Oliveira (Author), Alvino Maestri (Author), Alvina Clara Felix (Author), José Eduardo Levi (Author), Mauricio L Nogueira (Author), Mauricio A Martins (Author), José M Martinez-Navio (Author), Sebastian P Fuchs (Author), Stephen S Whitehead (Author), Dennis R Burton (Author), Ronald C Desrosiers (Author), Esper G Kallas (Author), David I Watkins (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The isolation of neutralizing monoclonal antibodies (nmAbs) against the Zika virus (ZIKV) might lead to novel preventative strategies for infections in at-risk individuals, primarily pregnant women. Here we describe the characterization of human mAbs from the plasmablasts of an acutely infected pati...