Induction of hepatic CYP3A4 expression by cholesterol and cholic acid: Alterations of gene expression, microsomal activity, and pharmacokinetics

Abstract Human cytochrome P450 3A4 (CYP3A4) is a drug‐metabolizing enzyme that is abundantly expressed in the liver and intestine. It is an important issue whether compounds of interest affect the expression of CYP3A4 because more than 30% of commercially available drugs are metabolized by CYP3A4. I...

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Main Authors: Genki Minegishi (Author), Yuka Kobayashi (Author), Mayu Fujikura (Author), Ayane Sano (Author), Yasuhiro Kazuki (Author), Kaoru Kobayashi (Author)
Format: Book
Published: Wiley, 2024-06-01T00:00:00Z.
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